Prague, Czech Republic, October 4-7, 2017

Scientific Program





Carolinum auditorium of Charles University, Prague, the oldest university on the European continent. Charles University was founded April 7, 1348 by Charles IV, King of Bohemia and Holy Roman Emporer, making it one of the oldest universities of the world. The ET-15 Welcome Reception will be held at the Carolinum.



Wednesday, October 4, 2017


15.00-17.00 Registration

18.00-20.00 Welcome Reception
Venue:
Carolinum Hall, Charles University


Thursday, October 5, 2017

Venue:
Hotel Duo, Prague


Morning Session


8.00-10.00 Symposium I

Endothelin signaling and mechanisms of endothelin action

Chairs: Pedro d´Orleans-Juste, Augusto C. Montezano


8.00-8.30 Key Note Lecture
Pharmacology of Endothelin Receptors: Prospects for the Next Decade
Anthony P. Davenport, University of Cambridge, UK

10.00-10.30 Coffee Break

10.30-12.00
Symposium II

Pharmacology, new drugs and drug interactions

Chairs: Janet Maguire, Anil Gulati

10.30-11.00 Key Note Lecture
Pharmacological Interventions Targeting the Endothelin Pathway: the Status Quo and Future Perspectives
Noriaki Emoto, Kobe Pharmaceutical University, Japan

12.00-12.15 ET-15 Conference Group Photograph

12.15-14.00 Lunch and Poster Session


Afternoon Session


14.00-15.30 Symposium III

Physiology and pathophysiology of cardiovascular function

Chairs: Noriaki Emoto, Pavel Jansa


14.00-14.30 Key Note Lecture
Endothelin in Resistance Artery Responses of Patients With Cardiovascular Disease
Jo De Mey, University of Odense, Denmark

15.30-16.00 Coffee Break


16.00-17.30
Symposium IV

Pulmonary function and pulmonary hypertension

Chairs: Martine Clozel, Vladimir Tesař


16.00-16.30 Key Note Lecture
Advances in Pathophysiology and Treatment of Chronic Pulmonary Hypertension
Pavel Jansa, Charles University, Czech Republic


18.00-21.00 Young Investigator Event



Friday, October 6, 2017


Morning Session


8.00-10.00
Symposium V

Metabolism, diabetes, metabolic syndrome, and obesity

Chairs: John Pernow, Carmine Cardillo


8.00-8.20 Invited Lecture
Bitter Taste of Diabetic Complications: Endothelin
Adviye Ergul, Augusta University, U.S.A.

8.20-8.40 Invited Lecture
Novel Aspects on Metabolism and Hypertension – The Nitrate-Nitrite-NO Pathway
Eddie Weitzberg, Karolinska Institutet, Sweden

10.00-10.30 Coffee Break


10.30-12.00
Symposium VI

Physiology and pathophysiology of renal function

Chairs: Neeraj Dhaun, Ivana Vaněčková


10.30-10.50 Invited Lecture
Endothelin Receptor Antagonism and Kidney Disease
Donald E. Kohan, University of Utah, U.S.A.

10.50-11.20 Invited Lecture
Endothelin and the Kidney Clock
David M. Pollock, University of Alabama, U.S.A.

12.00-14.00 Lunch and Poster Session


Afternoon Session


14.00-15.30
Symposium VII

Sex differences in physiology and disease

Chairs: Jennifer S. Pollock, Hiromi Yanagisawa


14.00-14.30 Key Note Lecture
The Interplay Between Endothelin-1 and Testosterone in the Activation of the Immune System
Rita C. Tostes, University of Sao Paulo, Brazil

15.30-16.00 Coffee Break

16.00-17.30
Symposium VIII

Neurophysiology, neurobiology, dementia and pain

Chairs: Adviye Ergul, Jo De Mey


16.00-16.30 Key Note Lecture
ETB Receptors Agonist, IRL-1620, for the Treatment of CNS Disorders
Anil Gulati, Midwestern University, U.S.A.

16.30-17.00 Key Note Lecture
A Genetic Variant Associated with Five Vascular Diseases is a Distal Regulator of Endothelin-1 Expression
Rajat M. Gupta, Harvard Medical School, Boston, USA

19.30 Pre-Banquet Reception

20.00 Concert and Conference Banquet



Saturday, October 7, 2017


Morning Session


8.00-10.00
Symposium IX

Immune system and inflammation

Chairs: Ariela Benigni, Josef Zicha


8.30-8.30 Key Note Lecture
Immune Mechanisms in Hypertension
Ernesto L. Schiffrin, McGill University, Montréal, Canada

10.00-10.30 Coffee Break

10.30-12.00
Symposium X

Cancer and metastasis

Chairs: Laura Rosano, Marilena Loizidou


10.30-11.00 Key Note Lecture
Targeting ET-1 Receptor/-Arrestin1 Signaling Circuit in Ovarian Cancer Treatment
Anna Bagnato, Regina Elena National Cancer Institute, Italy

11.30 - 12.30 Lunch


Afternoon Session


12.30-14.00
Symposium XI:
Role of endothelin in selected diseases

Chairs: David M. Pollock, Pierre-Louis Tharaux


12.30-13.30 Key Note Lecture
Balloon Angioplasty and Endothelin
Matthias Barton, University of Zurich, Switzerland

14.00-14.30 Coffee Break

14.30-16.00
Symposium XII:
Endothelin receptor antagonists in clinical trials

Chairs: David J. Webb, Věra Čertíková Chábová


14.30-14.55 Invited Lecture
From Endothelin Research to Drugs
Martine Clozel, Actelion, Switzerland

14.55-15.20 Invited Lecture
Dual Angiotensin II (Ang II) AT1 and Endothelin (ET) Type A Receptor Inhibition With Sparsentan in Primary Focal Segmental Glomerulosclerosis (FSGS): DUET Trial
Radko Komers, Retrophin, U.S.A.

15.20-15.45 Invited Lecture
Endothelin Antagonists in the Treatment of Diabetic Nephropathy – An Update
Vladimir Tesař, Charles University, Czech Republic


15.45-16.00
Award Ceremony
The Fourth Tomoh Masaki Award (2017)
Awards for best oral and best poster presentations


16.00-16.30
Highlights of ET-15
Special Lecture: Masashi Yanagisawa, University of Tsukuba, Japan

16.30-16.40 Closing remarks by the Conference Chairs
Ivana Vaněčková, Czech Academy of Sciences, Czech Republic
John Pernow, Karolinska Institutet, Sweden